Recombinant Rabbit monoclonal primary
CXCR3 Recombinant Rabbit Monoclonal Antibody [JA61-33] (ET1704-97)
Hela, A431, HepG2, HUVEC.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
C-X-C chemokine receptor type 3 antibody; CD 183 antibody; CD182 antibody; CD183 antibody; Chemokine (C X C motif) receptor 3 antibody; Chemokine (C X C) receptor 3 antibody; Chemokine CXC Motif Receptor 3 antibody; CKR L2 antibody; CKR-L2 antibody; CKRL2 antibody; CMKAR3 antibody; CXC-R3 antibody; CXCR-3 antibody; CXCR3 antibody; CXCR3_HUMAN antibody; G Protein Coupled Receptor 9 antibody; G protein-coupled receptor 9 antibody; GPR9 antibody; Interferon-inducible protein 10 receptor antibody; IP-10 receptor antibody; IP10 antibody; IP10 R antibody; IP10 receptor antibody; IP10-R antibody; IP10R antibody; Mig R antibody; Mig receptor antibody; Mig-R antibody; MIGR antibody
Belongs to the G-protein coupled receptor 1 family.
Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta. Isoform 2 is expressed in endothelial cells. Expressed in T-cells (at protein level).
Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding and subsequent signal transduction induction.; N-glycosylated.
The C-X-C or α chemokine family is characterized by a pair of cysteine residues separated by a single amino acid and primarily functions as chemoattractants for neutrophils. The C-X-C family includes IL-8, NAP-2, MSGA and stromal cell derived factor-1 (SDF-1). SDF-1 was originally described as a pre-B cell stimulatory factor, but has since been shown to function as a potent chemoattractant for T cells and monocytes but not neutrophils. Receptors for the C-X-C family are G protein-coupled, seven pass transmembrane domain proteins which include IL-8RA, IL-8RB, CXCR-3 and fusin (also designated LESTR or CXCR-4). CXCR-3, also known as IP-10/MIG receptor, mediates Ca2+ mobilization and chemotaxis in response to the C-X-C chemokines IP-10 and MIG. CXCR-3 is highly expressed in IL-2-activated T lymphocytes, but not in resting T lymphocytes, B lymphocytes, monocytes or granulocytes.