CXCL9 Recombinant Rabbit Monoclonal Antibody [PSH12-34] (HA723608)

UNIPROT #

Q07325

PROTEIN NAME

CXCL9

SYNONYMS

C-X-C motif chemokine 9 antibody;chemokine (C-X-C motif) ligand 9 antibody;CMK antibody;crg-10 antibody;CXCL9 antibody;CXCL9_HUMAN antibody;gamma interferon induced monokine antibody;Gamma-interferon-induced monokine antibody;HuMIG antibody;MIG antibody;monokine induced by gamma interferon antibody;monokine induced by interferon gamma antibody;Monokine induced by interferon-gamma antibody;SCYB9 antibody;Small inducible cytokine B9 antibody;small inducible cytokine subfamily B member 9 antibody;Small-inducible cytokine B9 antibody

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Chemokine (C-X-C motif) ligand 9 (CXCL9) is a small cytokine belonging to the CXC chemokine family that is also known as monokine induced by gamma interferon (MIG). The CXCL9 is one of the chemokine which plays role to induce chemotaxis, promote differentiation and multiplication of leukocytes, and cause tissue extravasation. The CXCL9/CXCR3 receptor regulates immune cell migration, differentiation, and activation. Immune reactivity occurs through recruitment of immune cells, such as cytotoxic lymphocytes (CTLs), natural killer (NK) cells, NKT cells, and macrophages. Th1 polarization also activates the immune cells in response to IFN-γ. Tumor-infiltrating lymphocytes are a key for clinical outcomes and prediction of the response to checkpoint inhibitors. In vivo studies suggest the axis plays a tumorigenic role by increasing tumor proliferation and metastasis. CXCL9 predominantly mediates lymphocytic infiltration to the focal sites and suppresses tumor growth. It is closely related to two other CXC chemokines called CXCL10 and CXCL11, whose genes are located near the gene for CXCL9 on human chromosome 4. CXCL9, CXCL10 and CXCL11 all elicit their chemotactic functions by interacting with the chemokine receptor CXCR3.