CXCL13 Recombinant Rabbit Monoclonal Antibody [PSH04-34] (HA722117)

UNIPROT #

O43927

PROTEIN NAME

CXCL13

SYNONYMS

ANGIE antibody;ANGIE2 antibody;B cell attracting chemokine 1 antibody;B cell-attracting chemokine 1 antibody;B lymphocyte chemoattractant antibody;B-cell chemoattractant antibody;B-cell-attracting chemokine 1 antibody;B-cell-homing chemokine (ligand for Burkitt's lymphoma receptor-1) antibody;BCA-1 antibody;BCA1 antibody;BLC antibody;BLR1L antibody;C-X-C motif chemokine 13 antibody;Chemokine (C-X-C motif) ligand 13 antibody;Chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant) antibody;Chemokine, CXC motif, ligand 13 antibody;CXC chemokine BLC antibody;CXCL13 antibody;CXL13_HUMAN antibody;SCYB13 antibody;Small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cell chemoattractant) antibody;Small inducible cytokine B13 antibody;Small inducible cytokine subfamily B, member 13 antibody;Small-inducible cytokine B13 antibody

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Chemokine (C-X-C motif) ligand 13 (CXCL13), also known as B lymphocyte chemoattractant (BLC) or B cell-attracting chemokine 1 (BCA-1), is a protein ligand that in humans is encoded by the CXCL13 gene. CXCL13 is a small chemokine belonging to the CXC chemokine family. As its other names suggest, this chemokine is selectively chemotactic for B cells belonging to both the B-1 and B-2 subsets, and elicits its effects by interacting with chemokine receptor CXCR5. CXCL13 and its receptor CXCR5 control the organization of B cells within follicles of lymphoid tissues and is expressed highly in the liver, spleen, lymph nodes, and gut of humans. The gene for CXCL13 is located on human chromosome 4 in a cluster of other CXC chemokines. In T lymphocytes, CXCL13 expression is thought to reflect a germinal center origin of the T cell, particularly a subset of T cells called follicular B helper T cells (or TFH cells). Hence, expression of CXCL13 in T-cell lymphomas, such as angioimmunoblastic T-cell lymphoma, is thought to reflect a germinal center origin of the neoplastic T-cells.