Cullin 4a Recombinant Rabbit Monoclonal Antibody [JU07-33] (ET7106-56)

UNIPROT #

Q13619

PROTEIN NAME

Cullin 4a

SYNONYMS

2810470J21Rik antibody;AW495282 antibody;CUL 4A antibody;CUL-4A antibody;Cul4a antibody;Cul4a protein antibody;CUL4A_HUMAN antibody;Cullin-4A antibody;MGC36573 antibody;MGC64071 antibody

SEQUENCE SIMILARITIES

Belongs to the cullin family.

POST-TRANSLATIONAL MODIFICATION

Neddylated. Deneddylated via its interaction with the COP9 signalosome (CSN) complex.; (Microbial infection) Deneddylated by Epstein-Barr virus BPLF1 leading to a S-phase-like environment that is required for efficient replication of the viral genome.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition.