Mouse monoclonal primary
CTHRC1 Mouse Monoclonal Antibody [5H1] (EM1701-36)
CTHRC1 recombinant protein, rat large intestine tissue, human kidney tissue, human placenta tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
Collagen triple helix repeat containing 1 antibody; Collagen triple helix repeat containing protein 1 antibody; Collagen triple helix repeat-containing protein 1 antibody; CTHR1_HUMAN antibody; Cthrc1 antibody; NMTC1 protein antibody; Protein NMTC1 antibody
Isoform 1 is expressed in calcified atherosclerotic plaque and chondrocyte-like cells.
Extracellular matrix. Secreted.
CTHRC1 (collagen triple helix repeat containing 1) is a 243 amino acid secreted protein that localizes to the extracellular matrix and contains one collagen-like domain. Expressed as two alternatively spliced isoforms, the first of which is expressed in calcified atherosclerotic plaque and chondrocyte-like cells, CTHRC1 is thought to function as a negative regulator of collagen matrix deposition and may also play a role in the stabilization of ligand-receptor interactions in the Wnt pathway. CTHRC1 is widely present in a variety of cancers, including melanoma and breast carcinoma, and may participate in cancer cell migration and cancer tissue invasion and metastasis. The gene encoding CTHRC1 maps to human chromosome 8, which consists of nearly 146 million base pairs, houses more than 800 genes and is associated with a variety of diseases and malignancies.
Ma, Ming-Ze et al.
CTHRC1 acts as a prognostic factor and promotes invasiveness of gastrointestinal stromal tumors by activating Wnt/PCP-Rho signaling. | Neoplasia (New York, N.Y.) 
Yang, Xiao-Mei et al.
CTHRC1 promotes human colorectal cancer cell proliferation and invasiveness by activating Wnt/PCP signaling. | International Journal of Clinical and Experimental Pathology 
Li, Jun et al.
Autocrine CTHRC1 activates hepatic stellate cells and promotes liver fibrosis by activating TGF-β_ signaling. | EbioMedicine