Rabbit polyclonal primary
CTGF Rabbit Polyclonal Antibody (ER1802-69)
Recombinant protein within human ctgf aa 147-293 / 349.
Mouse smooth muscle tissue lysate, HepG2, HUVEC, SiHa, human appendix tissue, human thyroid gland cancer tissue, human uterus tissue.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Protein affinity purified.
CCN 2 antibody; CCN family member 2 antibody; CCN2 antibody; Connective tissue growth factor antibody; Ctgf antibody; CTGF_HUMAN antibody; Hcs 24 antibody; Hcs24 antibody; Hypertrophic chondrocyte specific protein 24 antibody; Hypertrophic chondrocyte-specific gene product 24 antibody; Hypertrophic chondrocyte-specific protein 24 antibody IBP-8 antibody; IGF-binding protein 8 antibody; IGFBP-8 antibody; IGFBP8 antibody; Insulin like Growth Factor Binding Protein 8 antibody; Insulin-like growth factor-binding protein 8 antibody; MGC102839 antibody; NOV 2 antibody; NOV2 antibody
Belongs to the CCN family.
Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested.
Extracellular region or secreted.
Connective tissue growth factor (CTGF, also known as hypertrophic chondrocyte-specific gene product 24 or Hcs24), is a member of the CCN family of immediate early proteins, which are involved in cell proliferation, migration and matrix production. CTGF is a cysteine-rich peptide that is secreted by endothelial cells, fibroblasts, smooth muscle cells and myofibroblasts. Its expression is increased in various human and animal fibrotic diseases. Specifically, CTGF has been observed to be strongly upregulated in human proliferative and fibrogenic renal disease. In addition, CTGF is a growth factor for vascular smooth muscle cells (VSMC) and may play a similar role in promoting VSMC growth and migration in vitro.
Wu, Ming et al.
Reduced asymmetric dimethylarginine accumulation through inhibition of the type I protein arginine methyltransferases promotes renal fibrosis in obstructed kidneys. | Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology