CTDSPL Rabbit Polyclonal Antibody (ER1803-59)

UNIPROT #

O15194

PROTEIN NAME

CTDSPL

SYNONYMS

C3orf8 antibody;Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3 antibody;CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like antibody;CTD small phosphatase-like protein antibody;CTDSL_HUMAN antibody;CTDSP-like antibody;Ctdspl antibody;hYA22 antibody;N-like protein antibody;NIF-like protein antibody;NLI-interacting factor 1 antibody;Nuclear LIM interactor-interacting factor 1 antibody;Protein YA22 antibody;RB protein serine phosphatase from chromosome 3 antibody;RBSP3 antibody;SCP3 antibody;Small C-terminal domain phosphatase 3 antibody;Small CTD phosphatase 3 antibody

TISSUE SPECIFICITY

Expression is restricted to non-neuronal tissues.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation.