CSNK2B Recombinant Rabbit Monoclonal Antibody [JU37-62] (ET7106-67)

UNIPROT #

P67870

PROTEIN NAME

CSNK2B

SYNONYMS

Casein kinase 2 beta polypeptide antibody;Casein kinase II beta subunit antibody;Casein kinase II subunit beta antibody;CK II beta antibody;CK2B antibody;CK2N antibody;CSK2B antibody;CSK2B_HUMAN antibody;CSNK 2B antibody;csnk2b antibody;G5A antibody;MGC138222 antibody;MGC138224 antibody;Phosvitin antibody;Protein G5a antibody

SEQUENCE SIMILARITIES

Belongs to the casein kinase 2 subunit beta family.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by alpha subunit.

SUBCELLULAR LOCATION

Nucleus. Cytoplasm.

FUNCTION

Casein kinase I (also designated CKI) and casein kinase II (CKII) compose a family of serine/threonine protein kinases which are present in all eukaryotes examined to date. Casein kinase I family members, which include casein kinase Iα, Iγ, Iδ and Ie, have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. CKII is usually expressed as a tetrameric complex consisting of either an α2β2 or an αα'β2 structure. The a catalytic subunit is stimulated by the β regulatory subunit, which undergoes autophosphorylation. Casein kinase II activity is high in the cytosol and nucleus of proliferating and differentiating cells. Casein kinase II is known to phosphorylate more than 100 different substrates including nuclear oncoproteins, transcription factors and enzymes involved in DNA metabolism.