CSK Recombinant Rabbit Monoclonal Antibody [JE39-68] (HA722403)

UNIPROT #

P41240

PROTEIN NAME

CSK

SYNONYMS

C SRC antibody;C SRC kinase antibody;C src Tyrosine Kinase antibody;C-SRC kinase antibody;c-src tyrosine kinase antibody;Csk A antibody;CSK antibody;CSK_HUMAN antibody;CYTOPLASMIC TYROSINE KINASE antibody;EC 2.7.10.2 antibody;MGC112926 antibody;MGC117393 antibody;MGC154049 antibody;P60 Src antibody;Protein tyrosine kinase CYL antibody;Protein-tyrosine kinase CYL antibody;Proto oncogene tyrosine protein kinase antibody;Tyrosine protein kinase CSK antibody;Tyrosine-protein kinase CSK antibody;zgc:154049 antibody

SUBCELLULAR LOCATION

Cytoplasm, Cell membrane.

FUNCTION

Tyrosine-protein kinase CSK also known as C-terminal Src kinase is an enzyme that, in humans, is encoded by the CSK gene. This enzyme phosphorylates tyrosine residues located in the C-terminal end of Src-family kinases (SFKs) including SRC, HCK, FYN, LCK, LYN and YES1. This Non-receptor tyrosine-protein kinase plays an important role in the regulation of cell growth, differentiation, migration and immune response. CSK acts by suppressing the activity of the Src family of protein kinases by phosphorylation of Src family members at a conserved C-terminal tail site in Src. Upon phosphorylation by other kinases, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is then recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane and ultimately suppresses signaling through various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several effector molecules.