CRMP2 Recombinant Rabbit Monoclonal Antibody [JE31-53] (HA721560)

UNIPROT #

Q16555

PROTEIN NAME

CRMP2

SYNONYMS

Collapsin response mediator protein 2 antibody;Collapsin response mediator protein antibody;Collapsin response mediator protein hCRMP 2 antibody;CRAM antibody;CRMP 2 antibody;CRMP-2 antibody;CRMP2 antibody;DHPRP 2 antibody;DHPRP2 antibody;Dihydropyrimidinase 2 antibody;Dihydropyrimidinase like 2 antibody;Dihydropyrimidinase like 2 long form antibody;Dihydropyrimidinase related protein 2 antibody;Dihydropyrimidinase-related protein 2 antibody;DPYL 2 antibody;DPYL2 antibody;DPYL2_HUMAN antibody;DPYSL 2 antibody;Dpysl2 antibody;DRP-2 antibody;DRP2 antibody;Musunc 33 antibody;Musunc33 antibody;N2A3 antibody;TOAD 64 antibody;TOAD64 antibody;ULIP 2 protein antibody;ULIP-2 antibody;Ulip2 antibody;Unc-33-like phosphoprotein 2 antibody

SUBCELLULAR LOCATION

Cytoplasm. Cytoskeleton.

FUNCTION

Members of the CRMP family were discovered independently in different species by several groups working in parallel. Among the five members of the family, CRMP-2 was first identified in 1995. Group of researchers led by Goshima found out that CRMP-2 played a role in the transduction of the extracellular Semaphorin 3A (Sema3A), an inhibitory protein for axonal guidance in chick dorsal root ganglion (DRG). The protein was first named as CRMP-62 having a relative molecular mass of 62 kDa and later referred as CRMP-2. Concurrently, a 64 kDa protein named as TOAD-64 for Turned On After Division, was shown to increase significantly during the development of the cortex of the brain. The cDNA sequence of TOAD-64 corresponded to that of rat CRMP-2. In 1996, mouse CRMP-4, often referred to as Ulip for Unc-33 like phosphoprotein, was discovered by Byk and colleagues, using a rabbit polyclonal antiserum which recognized a 64 kDa mouse brain specific phosphoprotein. In the same year, several other studies cloned CRMPs-1-4 in rat and dihydropyrimidinase (DHPase) homologous sequence of CRMPs-1, -2, and -4 in human fetal brain. Finally, in 2000, CRMP-5 was discovered using two-hybrid screenings of brain libraries or purification from a proteic complex. In following researches, CRMPs were studied as target antigens for autoantibodies in various autoimmune neurodegenerative disorders.