CRLF2 Rabbit Polyclonal Antibody (HA500507)

UNIPROT #

Q9HC73

PROTEIN NAME

CRLF2

SYNONYMS

CRL 2 antibody;CRL2 antibody;CRLF 2 antibody;Crlf2 antibody;CRLF2_HUMAN antibody;CRLF2Y antibody;Cytokine receptor CRL2 precusor antibody;Cytokine receptor like 2 antibody;Cytokine receptor like factor 2 antibody;Cytokine receptor like factor 2 precursor antibody;Cytokine receptor-like 2 antibody;Cytokine receptor-like factor 2 antibody;IL XR antibody;IL-XR antibody;ILXR antibody;Thymic stromal derived lymphopoietin receptor antibody;Thymic stromal lymphopoietin protein receptor antibody;Thymic stromal lymphopoietin receptor antibody;TSLP receptor antibody;TSLPR antibody

SUBCELLULAR LOCATION

Cell membrane; Secreted.

FUNCTION

This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene.