CREBBP Rabbit Polyclonal Antibody (HA500191)

UNIPROT #

Q92793

PROTEIN NAME

CREBBP

SYNONYMS

CBP antibody;CBP_HUMAN antibody;CREB binding protein antibody;CREB-binding protein antibody;Crebbp antibody;Cyclic AMP responsive enhancer binding protein antibody;KAT3A antibody;RSTS antibody;RTS antibody;Rubinstein Taybi syndrome antibody

SUBCELLULAR LOCATION

Nucleus, Cytoplasm.

FUNCTION

This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms.