CREB1 Rabbit Polyclonal Antibody (R1309-14)

UNIPROT #

P16220

PROTEIN NAME

CREB1

SYNONYMS

Active transcription factor CREB antibody;cAMP response element binding protein 1 antibody;cAMP response element binding protein antibody;cAMP responsive element binding protein 1 antibody;cAMP-responsive element-binding protein 1 antibody;CREB antibody;CREB-1 antibody;CREB1 antibody;CREB1_HUMAN antibody;Cyclic AMP-responsive element-binding protein 1 antibody;MGC9284 antibody;OTTHUMP00000163864 antibody;OTTHUMP00000163865 antibody;OTTHUMP00000206660 antibody;OTTHUMP00000206662 antibody;OTTHUMP00000206667 antibody;Transactivator protein antibody

SEQUENCE SIMILARITIES

Belongs to the bZIP family.

POST-TRANSLATIONAL MODIFICATION

Stimulated by phosphorylation. Phosphorylation of both Ser-133 and Ser-142 in the SCN regulates the activity of CREB and participates in circadian rhythm generation. Phosphorylation of Ser-133 allows CREBBP binding. In liver, phosphorylation is induced by fasting or glucagon in a circadian fashion (By similarity). CREBL2 positively regulates phosphorylation at Ser-133 thereby stimulating CREB1 transcriptional activity (By similarity). Phosphorylated upon calcium influx by CaMK4 and CaMK2 on Ser-133. CaMK4 is much more potent than CaMK2 in activating CREB. Phosphorylated by CaMK2 on Ser-142. Phosphorylation of Ser-142 blocks CREB-mediated transcription even when Ser-133 is phosphorylated. Phosphorylated by CaMK1 (By similarity). Phosphorylation of Ser-271 by HIPK2 in response to genotoxic stress promotes CREB1 activity, facilitating the recruitment of the coactivator CBP. Phosphorylated at Ser-133 by RPS6KA3, RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli. Phosphorylated by TSSK4 on Ser-133.; Sumoylated with SUMO1. Sumoylation on Lys-304, but not on Lys-285, is required for nuclear localization of this protein. Sumoylation is enhanced under hypoxia, promoting nuclear localization and stabilization.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

CAMP responsive element binding protein 1, also known as CREB-1, is a protein that in humans is encoded by the CREB1 gene.This protein binds the cAMP response element, a DNA nucleotide sequence present in many viral and cellular promoters. The binding of CREB1 stimulates transcription.This protein is a CREB transcription factor that is a member of the leucine zipper family of DNA-binding proteins.CREB1 is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms.