CREB Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [PSH15-48] (HA751563)

UNIPROT #

P16220

PROTEIN NAME

CREB

SYNONYMS

Active transcription factor CREB antibody;cAMP response element binding protein 1 antibody;cAMP response element binding protein antibody;cAMP responsive element binding protein 1 antibody;cAMP-responsive element-binding protein 1 antibody;CREB antibody;CREB-1 antibody;CREB1 antibody;CREB1_HUMAN antibody;Cyclic AMP-responsive element-binding protein 1 antibody;MGC9284 antibody;OTTHUMP00000163864 antibody;OTTHUMP00000163865 antibody;OTTHUMP00000206660 antibody;OTTHUMP00000206662 antibody;OTTHUMP00000206667 antibody;Transactivator protein antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

CREB-TF (CREB, cAMP response element-binding protein) is a cellular transcription factor. It binds to certain DNA sequences called cAMP response elements (CRE), thereby increasing or decreasing the transcription of the genes. CREB was first described in 1987 as a cAMP-responsive transcription factor regulating the somatostatin gene. Genes whose transcription is regulated by CREB include: c-fos, BDNF, tyrosine hydroxylase, numerous neuropeptides (such as somatostatin, enkephalin, VGF, corticotropin-releasing hormone), and genes involved in the mammalian circadian clock (PER1, PER2). CREB is closely related in structure and function to CREM (cAMP response element modulator) and ATF-1 (activating transcription factor-1) proteins. CREB proteins are expressed in many animals, including humans. CREB has a well-documented role in neuronal plasticity and long-term memory formation in the brain and has been shown to be integral in the formation of spatial memory. CREB downregulation is implicated in the pathology of Alzheimer's disease and increasing the expression of CREB is being considered as a possible therapeutic target for Alzheimer's disease. CREB also has a role in photoentrainment in mammals.