Creatine kinase B type Recombinant Rabbit Monoclonal Antibody [PSH09-32] (HA723090)

UNIPROT #

P12277

PROTEIN NAME

Creatine kinase B type

SYNONYMS

B CK antibody;B-CK antibody;BB-CK antibody;BCK antibody;Brain creatine kinase antibody;Ckb antibody;CKBB antibody;Creatine kinase B antibody;Creatine kinase B chain antibody;Creatine kinase B type antibody;Creatine kinase B-type antibody;Creatine Kinase BB Isoenzyme antibody;Creatine kinase brain antibody;Creatine kinase brain type antibody;Creatine phosphokinase BB antibody;Epididymis luminal protein 211 antibody;Epididymis secretory protein Li 29 antibody;HEL 211 antibody;HEL S 29 antibody;KCRB_HUMAN antibody

SUBCELLULAR LOCATION

Cytoplasm, cytosol, Mitochondrion, Cell membrane.

FUNCTION

Brain-type creatine kinase also known as CK-BB is a creatine kinase that in humans is encoded by the CKB gene. The protein encoded by this gene, CK-BB, consists of a homodimer of two identical brain-type CK-B subunits. BB-CK is a cytoplasmic enzyme involved in cellular energy homeostasis, with certain fractions of the enzyme being bound to cell membranes, ATPases, and a variety of ATP-requiring enzymes in the cell. There, CK-BB forms tightly coupled microcompartments for in situ regeneration of ATP that has been used up. The encoded protein reversibly catalyzes the transfer of "energy-rich" phosphate between ATP and creatine or between phospho-creatine (PCr) and ADP. Its functional entity is a homodimer (CK-BB) in brain and smooth muscle as well as in other tissues and cells such as neuronal cells, retina, kidney, bone, etc. In heart, a heterodimer (CK-MB) shahil consisting of one CK-B brain-type CK subunit and one CK-M muscle-type CK subunit is prominently expressed. The encoded CK-BB and CK-MB proteins are members of the ATP:guanido phosphotransferase protein family.