CPT1A Recombinant Rabbit Monoclonal Antibody [PSH10-94] (HA723261)

UNIPROT #

P97742

PROTEIN NAME

CPT1A

SYNONYMS

Carnitine O palmitoyltransferase 1 liver isoform antibody;Carnitine O palmitoyltransferase I antibody;Carnitine O palmitoyltransferase I liver isoform antibody;Carnitine O-palmitoyltransferase 1 antibody;Carnitine O-palmitoyltransferase I antibody;Carnitine palmitoyltransferase 1A (liver) antibody;Carnitine palmitoyltransferase 1A antibody;Carnitine palmitoyltransferase I antibody;Carnitine palmitoyltransferase I liver antibody;CPT 1 antibody;CPT I antibody;CPT1 antibody;CPT1 L antibody;CPT1-L antibody;Cpt1a antibody;CPT1A_HUMAN antibody;CPTI antibody;CPTI-L antibody;L CPT1 antibody;liver isoform antibody

SUBCELLULAR LOCATION

Mitochondrion outer membrane.

FUNCTION

Carnitine palmitoyltransferase I (CPT1) also known as carnitine acyltransferase I, CPTI, CAT1, CoA:carnitine acyl transferase (CCAT), or palmitoylCoA transferase I, is a mitochondrial enzyme responsible for the formation of acyl carnitines by catalyzing the transfer of the acyl group of a long-chain fatty acyl-CoA from coenzyme A to l-carnitine. The product is often Palmitoylcarnitine (thus the name), but other fatty acids may also be substrates. It is part of a family of enzymes called carnitine acyltransferases. This "preparation" allows for subsequent movement of the acyl carnitine from the cytosol into the intermembrane space of mitochondria. Three isoforms of CPT1 are currently known: CPT1A, CPT1B, and CPT1C. CPT1 is associated with the outer mitochondrial membrane. This enzyme can be inhibited by malonyl CoA, the first committed intermediate produced during fatty acid synthesis. Its role in fatty acid metabolism makes CPT1 important in many metabolic disorders such as diabetes. Since its crystal structure is not known, its exact mechanism of action remains to be determined.