CPN1 Rabbit Polyclonal Antibody (HA500462)

UNIPROT #

P15169

PROTEIN NAME

CPN1

SYNONYMS

ACBP antibody;Anaphylatoxin inactivator antibody;Arginine carboxypeptidase antibody;Carboxypeptidase N catalytic chain antibody;Carboxypeptidase N polypeptide 1 50 kD antibody;Carboxypeptidase N polypeptide 1 antibody;Carboxypeptidase N small subunit antibody;Carboxypeptidase N subunit 1 antibody;CBPN_HUMAN antibody;CPN antibody;CPN1 antibody;Kininase 1 antibody;Kininase-1 antibody;Kininase1 antibody;Lysine carboxypeptidase antibody;Plasma carboxypeptidase B antibody;SCPN antibody;Serum carboxypeptidase N antibody

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Carboxypeptidase N catalytic chain is an enzyme that in humans is encoded by the CPN1 gene.Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer composed of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency.In melanocytic cells CPN1 gene expression may be regulated by MITF.