Lane 1: Human skeletal muscle tissue lysate
Lane 2: Rat bone marrow lysate
Recombinant Rabbit monoclonal primary
COPS3/CSN3 Recombinant Rabbit Monoclonal Antibody [JE47-48] (ET7109-60)
Synthetic peptide within c terminal human cops3/csn3.
Human skeletal muscle tissue, Rat bone marrow, A431, HCT116, rat heart tissue, human liver cancer tissue, human breast tissue, human pancreas tissue, mouse kidney tissue, mouse heart tissue, 293.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Constitutive photomorphogenic homolog subunit 3 antibody; COP 9 (constitutive photomorphogenic) subunit 3 antibody; COP 9 complex homolog subunit 3 antibody; COP 9 complex S3 antibody; COP 9 complex subunit 3 antibody; COP 9 constitutive photomorphogenic homolog subunit 3 antibody; COP 9 homolog antibody; COP 9 signalosome complex subunit 3 antibody; COP 9 signalosome subunit 3 antibody; COP 9 subunit 3 antibody; COP9 (constitutive photomorphogenic) subunit 3 antibody; COP9 complex homolog subunit 3 antibody; COP9 complex S3 antibody; COP9 complex subunit 3 antibody; COP9 constitutive photomorphogenic homolog subunit 3 antibody; COP9 homolog antibody; COP9 signalosome complex subunit 3 antibody; COP9 signalosome subunit 3 antibody; COP9 subunit 3 antibody; COPS 3 antibody; cops3 antibody; CSN 3 antibody; CSN3 antibody; CSN3_HUMAN antibody; JAB 1 containing signalosome subunit 3 antibody; JAB1 containing signalosome subunit 3 antibody; JAB1-containing signalosome subunit 3 antibody; SGN 3 antibody; SGN3 antibody; Signalosome subunit 3 antibody
Belongs to the CSN3 family.
Widely expressed. Expressed at high level in heart and skeletal muscle.
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.