Complement C3 Recombinant Rabbit Monoclonal Antibody [PSH18-31] (HA723984)

UNIPROT #

P01027

PROTEIN NAME

Complement C3

SYNONYMS

Acylation stimulating protein cleavage product antibody;AHUS5 antibody;ARMD9 antibody;ASP antibody;C3 and PZP like alpha 2 macroglobulin domain containing protein 1 antibody;C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1 antibody;C3 antibody;CO3_HUMAN antibody;Complement C3 antibody;Complement C3c alpha' chain fragment 2 antibody;Complement component 3 antibody;Complement factor 3 antibody;CPAMD1 antibody;HEL S 62p antibody

SUBCELLULAR LOCATION

Secreted.

FUNCTION

C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. A rare defect of the complement classical pathway. Patients develop recurrent, severe, pyogenic infections because of ineffective opsonization of pathogens. Some patients may also develop autoimmune disorders, such as arthralgia and vasculitic rashes, lupus-like syndrome and membranoproliferative glomerulonephritis.