COMP Mouse Monoclonal Antibody [A10H2] (HA601354)

UNIPROT #

P49747

PROTEIN NAME

COMP

SYNONYMS

cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple) antibody;Cartilage oligomeric matrix protein antibody;Cartilage oligomeric matrix protein precursor antibody;COMP antibody;COMP_HUMAN antibody;EDM 1 antibody;EDM1 antibody;EPD 1 antibody;EPD1 antibody;Epiphyseal dysplasia 1 antibody;Epiphyseal dysplasia 1 multiple antibody;Epiphyseal dysplasia multiple 1 antibody;MED antibody;MGC13181 antibody;MGC149768 antibody;PSACH antibody;pseudoachondroplasia (epiphyseal dysplasia 1, multiple) antibody;Pseudoachondroplasia antibody;THBS 5 antibody;THBS5 antibody;Thrombospondin 5 antibody;Thrombospondin-5 antibody;Thrombospondin5 antibody;TSP5 antibody

SUBCELLULAR LOCATION

Secreted, extracellular space, extracellular matrix.

FUNCTION

Cartilage oligomeric matrix protein (COMP), also known as thrombospondin-5, is an extracellular matrix (ECM) protein primarily present in cartilage. In humans it is encoded by the COMP gene. The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfide bonds. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). COMP is a marker of cartilage turnover. It is present in high quantities in fibrotic scars and systemic sclerosis, and it appears to have a role in vascular wall remodeling.