CNOT1 Rabbit Polyclonal Antibody (HA500466)

UNIPROT #

A5YKK6

PROTEIN NAME

CNOT1

SYNONYMS

adrenal gland protein AD-005 antibody;CCR4 NOT transcription complex subunit 1 isoform b antibody;CCR4-associated factor 1 antibody;hNOT1 antibody;Negative regulator of transcription subunit 1 homolog antibody;NOT1 (negative regulator of transcription 1 yeast) homolog antibody;NOT1H antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES) cell identity.