CLIC4 Rabbit Polyclonal Antibody (ER1902-48)

UNIPROT #

Q9Y696

PROTEIN NAME

CLIC4

SYNONYMS

Chloride intracellular channel 4 antibody;Chloride intracellular channel 4 (mitochondrial) antibody;Chloride intracellular channel 4 like antibody;Chloride intracellular channel protein 4 antibody;Clic4 antibody;CLIC4_HUMAN antibody;CLIC4L antibody;DKFZP566G223 antibody;FLJ38640 antibody;H1 antibody;HUH1 antibody;Intracellular chloride ion channel protein p64H1 antibody;MC3S5 antibody;mtCLIC antibody;p64H1 antibody

SEQUENCE SIMILARITIES

Belongs to the chloride channel CLIC family.

TISSUE SPECIFICITY

Detected in epithelial cells from colon, esophagus and kidney (at protein level). Expression is prominent in heart, kidney, placenta and skeletal muscle.

SUBCELLULAR LOCATION

Cell junction, Cell membrane, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Mitochondrion, Nucleus.

FUNCTION

Chloride intracellular channel 4, also known as CLIC4, is a eukaryotic gene.Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits an intracellular vesicular pattern in PANC-1 cells (pancreatic cancer cells).Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis).