Lane 1: human stomach tissue lysate
Lane 2: AGS cell lysate
Rabbit polyclonal primary
Claudin 18.1 Rabbit Polyclonal Antibody (ER1902-11)
Synthetic peptide within human claudin18 aa 28-80.
Human stomach tissue lysate, AGS cell lysate, F9.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Peptide affinity purified
Predicted band size 28 kDa
Claudin 18.1 antibody; Claudin-18.1 antibody; CLD18.1_HUMAN antibody; CLDN18.1 antibody; SFTA5 antibody; SFTPJ antibody
Belongs to the claudin family.
Isoform A1: Expression is restricted to the lung. Isoform A2: Expression is restricted to the stomach mucosa where it is predominantly observed in the epithelial cells of the pit region and the base of the gastric glands including exocrine and endocrine cells (at protein level).
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.