Recombinant Rabbit monoclonal primary
Clathrin heavy chain Recombinant Rabbit Monoclonal Antibody [JA53-02] (ET1704-50)
Hela, PC12, human adrenal gland tissue, human colon cancer tissue, human kidney tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
Clathrin heavy chain
CHC17 antibody; Clathrin heavy chain antibody; Clathrin heavy chain 1 antibody; Clathrin heavy chain 2 antibody; Clathrin heavy chain like 1 antibody; Clathrin heavy chain on chromosome 17 antibody; Clathrin heavy polypeptide antibody; CLH 17 antibody; CLH 22 antibody; CLH-17 antibody; CLH1_HUMAN antibody; CLH17 antibody; CLH22 antibody; CLTC antibody; CLTCL antibody; CLTCL1 antibody; CLTCL2 antibody; CLTD antibody; Hc antibody; KIAA0034 antibody
Belongs to the clathrin heavy chain family.
Maximal levels in skeletal muscle. High levels in heart and testis. Low expression detected in all other tissues.
Cytoplasmic vesicle membrane.
Clathrin is a major cytosolic coat protein in pits and vesicles originating from the plasma membrane and the trans-Golgi network. In receptor-mediated endocytosis, receptor proteins are englufed by clathrin-coated vesicles. Clathrin is composed of three heavy chains and three light chains which associate non-covalently to form a triskelion structure. Clathrin heavy chain (HC) is composed of a terminal globular domain, a distal segment and a proximal segment containing a light chain binding site. The proximal segment of the Clathrin HC protein is essential for interactions between clathrin heavy chains and light chains which result in the formation of the triskelion structure.