Chromogranin-A(C-term) Mouse Monoclonal Antibody [D11-2] (EM0407-24)

UNIPROT #

P10645

PROTEIN NAME

Chromogranin-A(C-term)

SYNONYMS

beta Granin antibody;betagranin (N-terminal fragment of chromogranin A) antibody;catestatin antibody;CgA antibody;CHG A antibody;Chga antibody;chromofungin antibody;Chromogranin A antibody;Chromogranin A parathyroid secretory protein 1 antibody;Chromogranin A precursor antibody;ChromograninA antibody;CMGA_HUMAN antibody;ER-37 antibody;Pancreastatin antibody;Parastatin antibody;Parathyroid secretory protein 1 antibody;Pituitary secretory protein I antibody;Secretory protein I antibody;SP I antibody;SP-I antibody;SP1 antibody;SPI antibody;Vasostatin antibody;Vasostatin I antibody;Vasostatin II antibody

SEQUENCE SIMILARITIES

Belongs to the chromogranin/secretogranin protein family.

TISSUE SPECIFICITY

GE-25 is found in the brain.

POST-TRANSLATIONAL MODIFICATION

Sulfated on tyrosine residues and/or contains sulfated glycans.; O-glycosylated with core 1 or possibly core 8 glycans.; Proteolytic processing gives rise to an additional longer form of catestatin (residues 358-390) which displays a less potent catecholamine release-inhibitory activity. Plasmin-mediated proteolytic processing can give rise to additional shorter and longer forms of catestatin peptides.

SUBCELLULAR LOCATION

Secreted. Secretory vesicle lumen.

FUNCTION

The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two other peptides, catestatin and chromofungin, have antimicrobial activity and antifungal activity, respectively. Two transcript variants encoding different isoforms have been found for this gene.