Chromogranin A Recombinant Rabbit Monoclonal Antibody [JM103-7] (ET1703-08)

UNIPROT #

P10645

PROTEIN NAME

Chromogranin A

SYNONYMS

beta Granin antibody;betagranin (N-terminal fragment of chromogranin A) antibody;catestatin antibody;CgA antibody;CHG A antibody;Chga antibody;chromofungin antibody;Chromogranin A parathyroid secretory protein 1 antibody;Chromogranin A precursor antibody;ChromograninA antibody;CMGA_HUMAN antibody;ER-37 antibody;Pancreastatin antibody;Parastatin antibody;Parathyroid secretory protein 1 antibody;Pituitary secretory protein I antibody;Secretory protein I antibody;SP I antibody;SP-I antibody;SP1 antibody;SPI antibody;Vasostatin antibody;Vasostatin I antibody;Vasostatin II antibody

SEQUENCE SIMILARITIES

Belongs to the chromogranin/secretogranin protein family.

TISSUE SPECIFICITY

GE-25 is found in the brain.

POST-TRANSLATIONAL MODIFICATION

Sulfated on tyrosine residues and/or contains sulfated glycans.; O-glycosylated with core 1 or possibly core 8 glycans.; Proteolytic processing gives rise to an additional longer form of catestatin (residues 358-390) which displays a less potent catecholamine release-inhibitory activity. Plasmin-mediated proteolytic processing can give rise to additional shorter and longer forms of catestatin peptides.

SUBCELLULAR LOCATION

Cytoplasmic vesicle, Secreted.

FUNCTION

Chromogranin A or parathyroid secretory protein 1 (gene name CHGA) is a member of the granin family of neuroendocrine secretory proteins. As such, it is located in secretory vesicles of neurons and endocrine cells such as islet beta cell secretory granules in the pancreas. In humans, chromogranin A protein is encoded by the CHGA gene. Chromogranin A is the precursor to several functional peptides including vasostatin-1, vasostatin-2, pancreastatin, catestatin and parastatin. These peptides negatively modulate the neuroendocrine function of the releasing cell (autocrine) or nearby cells (paracrine). Chromogranin A induces and promotes the generation of secretory granules such as those containing insulin in pancreatic islet beta cells.