CHRNA7 Recombinant Rabbit Monoclonal Antibody [PSH19-20] (HA724054)

UNIPROT #

P36544

PROTEIN NAME

CHRNA7

SYNONYMS

7nAChR antibody;a7 nicotinic acetylcholine receptor antibody;acetylcholine receptor neuronal nicotinic alpha-7 subunit antibody;ACHA7_HUMAN antibody;AChR antibody;Acra7 antibody;alpha 7 neuronal nicotinic acetylcholine receptor antibody;alpha-7 nicotinic cholinergic receptor subunit antibody;alpha7 antibody;cholinergic receptor neuronal nicotinic alpha polypeptide 7 antibody;cholinergic receptor nicotinic alpha 7 (neuronal) antibody;cholinergic receptor nicotinic alpha 7 antibody;cholinergic receptor nicotinic alpha polypeptide 7 antibody;CHRNA7 antibody;CHRNA7-2 antibody;NACHRA7 antibody;neuronal acetylcholine receptor protein alpha-7 chain antibody;Neuronal acetylcholine receptor subunit alpha-7 antibody

SUBCELLULAR LOCATION

Postsynaptic cell membrane, cell membrane

FUNCTION

Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators.CHRNA7 forms homopentameric neuronal acetylcholine receptors abundantly expressed in the central nervous system, characterized by fast desensitization and high calcium permeability.In T cells, activation induces metabotropic signaling that results in an increase of intracellular Ca2+ concentrations, independent of ionotropic receptor functions (PubMed:17709503). In macrophages, required for acetylcholine-mediated inhibition of TNF and other inflammatory cytokine release