CHMP2A Rabbit Polyclonal Antibody (HA500070)

UNIPROT #

O43633

PROTEIN NAME

CHMP2A

SYNONYMS

BC 2 antibody;BC2 antibody;Charged multivesicular body protein 2a antibody;CHM2A_HUMAN antibody;CHMP2 antibody;CHMP2a antibody;Chromatin modifying protein 2a antibody;Chromatin-modifying protein 2a antibody;hVps2 1 antibody;hVps2-1 antibody;putative breast adenocarcinoma marker antibody;Putative breast adenocarcinoma marker BC-2 antibody;Putative breast adenocarcinoma marker BC2 antibody;Vacuolar protein sorting associated protein 2 1 antibody;Vacuolar protein sorting-associated protein 2-1 antibody;Vps2 1 antibody;VPS2 antibody;Vps2-1 antibody;VPS2A antibody

SUBCELLULAR LOCATION

Late endosome membrane.

FUNCTION

Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.