CHCHD2 Recombinant Rabbit Monoclonal Antibody [PSH13-87] (HA723580)

UNIPROT #

Q9Y6H1

PROTEIN NAME

CHCHD2

SYNONYMS

16.7kD protein antibody;Aging Associated Gene 10 Protein antibody;Aging-associated gene 10 protein antibody;C7orf17 antibody;CHCH2_HUMAN antibody;CHCHD 2 antibody;CHCHD2 antibody;Coiled Coil Helix Coiled Coil Helix Domain Containing 2 antibody;Coiled coil helix coiled coil helix domain containing protein 2, mitochondrial antibody;Coiled-coil-helix-coiled-coil-helix domain-containing protein 2, mitochondrial antibody;HCV NS2 trans regulated protein antibody;HCV NS2 trans-regulated protein antibody;NS2TP antibody

SUBCELLULAR LOCATION

Nucleus, Mitochondrion, Mitochondrion intermembrane space.

FUNCTION

Coiled-coil-helix-coiled-coil-helix domain containing 2 is a protein that in humans is encoded by the CHCHD2 gene. The protein encoded by this gene belongs to a class of eukaryotic CX(9)C proteins characterized by four cysteine residues spaced ten amino acids apart from one another. These residues form disulfide linkages that define a CHCH fold. In response to stress, the protein translocates from the mitochondrial intermembrane space to the nucleus where it binds to a highly conserved 13 nucleotide oxygen responsive element in the promoter of cytochrome oxidase 4I2, a subunit of the terminal enzyme of the electron transport chain. In concert with recombination signal sequence-binding protein J, binding of this protein activates the oxygen responsive element at four percent oxygen. In addition, it has been shown that this protein is a negative regulator of mitochondria-mediated apoptosis. In response to apoptotic stimuli, mitochondrial levels of this protein decrease, allowing BCL2-associated X protein to oligomerize and activate the Caspase Cascade. Pseudogenes of this gene are found on multiple chromosomes. Alternative splicing results in multiple transcript variants.