cGAS Rabbit Polyclonal Antibody (HA500023)

UNIPROT #

Q8N884

PROTEIN NAME

cGAS

SYNONYMS

C6orf150 antibody;cGAMP synthase antibody;cGAS antibody;CGAS_HUMAN antibody;cGMP Synthase antibody;Chromosome 6 open reading frame 150 antibody;Cyclic GMP-AMP synthase antibody;h-cGAS antibody;Hypothetical protein LOC115004 antibody;Mab 21 domain containing 1 antibody;Mab-21 domain-containing protein 1 antibody;MB21D1 antibody;MGC131892 antibody;MGC142166 antibody;MGC142168 antibody;OTTHUMP00000016743 antibody;OTTHUMP00000039330 antibody;protein MB21D1 antibody;Uncharacterized protein C6orf150 antibody

SUBCELLULAR LOCATION

Cell membrane, cytosol, nucleus.

FUNCTION

cGAS Antibody (C-1) is a high quality monoclonal cGAS antibody (also designated cGAS antibody) suitable for the detection of the cGAS protein of human origin. cGAS Antibody (C-1) is available as the non-conjugated anti-cGAS antibody. The presence of foreign DNA in the cytoplasm induces an antiviral host immune response. DNA in the cytoplasm triggers the production of interferons by activating and synthesis of second messenger cyclic guanosine monophosphate-adenosine monophosphate (cyclic GMP-AMP, or cGAMP). cGAS (cyclic GMP-AMP synthase), also known as MB21D1 (Mab-21 domain containing 1), h-cGAS or C6orf150, is a 522 amino acid cytoplasmic nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. cGAS is suggested to have antiviral activity by acting as a key cytosolic DNA sensor. cGAS binds to cytosolic DNA, which leads to cGAMP synthesis and activation of TMEM173, thereby trigger type-I interferon production. Expressed in monocytic cell line THP1, cGAS exists as two alternatively spliced isoforms and is encoded by a gene located on human chromosome 6q13.