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CEACAM6 Rabbit Polyclonal Antibody (ER1902-54)

Price: Regular price $315.00

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Catalog# ER1902-54

Rabbit Polyclonal to CEACAM6

Tested for

  • WB

  • IHC-P

  • IF-Cell

  • FC

React with

  • Human

  • Mouse

  • Rat

Specifications

Product Type

Rabbit polyclonal primary

Product Name

CEACAM6 Rabbit Polyclonal Antibody (ER1902-54)

Immunogen

Recombinant protein within human ceacam6 aa 49-224 / 344.

Host

Rabbit

Positive Control

JAR cell lysate, rat lung tissue lysate, MCF-7 cell lysate, human lung tissue lysate, LOVO, MCF-7, human lung cancer tissue, human colon cancer tissue, human appendix cancer tissue.

Conjugation

Unconjugated

Clonality

Polyclonal

APPLICATION DILUTION

  • WB

  • 1:500-1:1,000

  • IHC-P

  • 1:50-1:200

  • IF-Cell

  • 1:50-1:200

  • FC

  • 1:50-1:100

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

Predicted band size: 37 kDa

Isotype

IgG

TARGET

UNIPROT #

P40199

PROTEIN NAME

CEACAM6

SYNONYMS

Carcinoembryonic antigen related cell adhesion molecule 6 antibody;Carcinoembryonic antigen related cell adhesion molecule 6 (non specific cross reacting antigen) antibody;Carcinoembryonic antigen-related cell adhesion molecule 6 antibody;CD 66c antibody;CD66c antibody;CD66c antigen antibody;CEA LIKE PROTEIN antibody;CEACAM 6 antibody;CEACAM6 antibody;CEAL antibody;CEAM6_HUMAN antibody;MGC93832 antibody;NCA antibody;Non specific cross reacting antigen antibody;Non-specific crossreacting antigen antibody;Normal cross reacting antigen antibody;Normal cross-reacting antigen antibody

SEQUENCE SIMILARITIES

Belongs to the immunoglobulin superfamily. CEA family.

TISSUE SPECIFICITY

Expressed in neutrophils. Expressed in columnar epithelial and goblet cells of the colon. Expressed in numerous tumor cell lines (at protein level).

POST-TRANSLATIONAL MODIFICATION

Glycosylated.

SUBCELLULAR LOCATION

Cell membrane, Membrane.

FUNCTION

Cell surface glycoprotein that plays a role in cell adhesion and tumor progression . Intercellular adhesion occurs in a calcium- and fibronectin-independent manner. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8 . Heterophilic interaction with CEACAM8 occurs in activated neutrophils . Plays a role in neutrophil adhesion to cytokine-activated endothelial cells . Plays a role as an oncogene by promoting tumor progression; positively regulates cell migration, cell adhesion to endothelial cells and cell invasion . Also involved in the metastatic cascade process by inducing gain resistance to anoikis of pancreatic adenocarcinoma and colorectal carcinoma cells .

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