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Cdk7 Recombinant Rabbit Monoclonal Antibody [JJ203-01] (ET1701-25)

Price: Regular price $385.00

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Catalog# ET1701-25

Rabbit Monoclonal to Cdk7

Tested for

  • WB

  • IF-Cell

  • IF-Tissue

  • IHC-P

  • FC

React with

  • Human

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free

Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

Cdk7 Recombinant Rabbit Monoclonal Antibody [JJ203-01] (ET1701-25)

Immunogen

Recombinant protein within human cdk7 aa 151-346 / 346.

Host

Rabbit

Positive Control

A431, Hela, HepG2, 293, human breast carcinoma tissue, human lung carcinoma tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

JJ203-01

APPLICATION DILUTION

  • WB

  • 1:500

  • IF-Cell

  • 1:100-1:500

  • IF-Tissue

  • 1:100-1:500

  • IHC-P

  • 1:50-1:200

  • FC

  • 1:50-1:100

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 39 kDa

Isotype

IgG

TARGET

UNIPROT #

P50613

PROTEIN NAME

Cdk7

SYNONYMS

39 kDa protein kinase antibody;CAK antibody;CAK1 antibody;Cdk activating kinase antibody;CDK-activating kinase 1 antibody;CDK-activating kinase antibody;cdk7 antibody;CDK7_HUMAN antibody;CDKN7 antibody;Cell division protein kinase 7 antibody;Cyclin dependent kinase 7 antibody;cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) antibody;Cyclin-dependent kinase 7 antibody;HCAK antibody;Homolog of Xenopus MO15 Cdk activating kinase antibody;Kinase subunit of CAK antibody;MO15 antibody;MO15, Xenopus, homolog of antibody;P39 Mo15 antibody;p39MO15 antibody;Serine threonine kinase Stk1 antibody;Serine/threonine protein kinase 1 antibody;Serine/threonine protein kinase MO15 antibody;STK1 antibody;TFIIH basal transcription factor complex kinase subunit antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

TISSUE SPECIFICITY

Ubiquitous.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation of Ser-164 during mitosis inactivates the enzyme. Phosphorylation of Thr-170 is required for activity. Phosphorylated at Ser-164 and Thr-170 by CDK2.

SUBCELLULAR LOCATION

Nucleus, Cytoplasm, perinuclear region.

FUNCTION

Cyclin-dependent kinase 7, or cell division protein kinase 7, is an enzyme that in humans is encoded by the CDK7 gene. The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle.

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