CDK5RAP3 Rabbit Polyclonal Antibody (ER1902-72)

UNIPROT #

Q96JB5

PROTEIN NAME

CDK5RAP3

SYNONYMS

C53 antibody;CDK5 activator binding protein C53 antibody;CDK5 activator-binding protein C53 antibody;CDK5 regulatory subunit associated protein 3 antibody;CDK5 regulatory subunit-associated protein 3 antibody;Cdk5rap3 antibody;CK5P3_HUMAN antibody;HSF 27 antibody;HSF27 antibody;IC53 antibody;Ischemic heart CDK5 activator binding protein C53 antibody;LXXLL/leucine zipper containing ARFbinding protein antibody;LZAP antibody;MST016 antibody;OK/SW cl.114 antibody;PP1553 antibody;Protein HSF-27 antibody

SEQUENCE SIMILARITIES

Belongs to the CDK5RAP3 family.

TISSUE SPECIFICITY

Ubiquitously expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform 3 is expressed in kidney, liver, skeletal muscle and placenta.

POST-TRANSLATIONAL MODIFICATION

May be phosphorylated by CDK5.; Ubiquitinated. Probably triggers proteasomal degradation and is negatively regulated by UFL1.; May be ufmylated.; Cleaved by caspases early during apoptosis, the resulting peptides may play a role in rupture of the nuclear envelope.

SUBCELLULAR LOCATION

Cytoplasm, Cytoskeleton, Nucleus.

FUNCTION

Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation . Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation . Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint. Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation . May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress . May also play a role in the rupture of the nuclear envelope during apoptosis . May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1