Lane 1: HUVEC
Lane 2: Hela
Recombinant Rabbit monoclonal primary
CDC42EP1 Recombinant Rabbit Monoclonal Antibody [SD08-54] (ET1612-95)
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
55 kDa bone marrow stromal/endothelial cell protein antibody; Binder of Rho GTPases 5 antibody; Bone marrow stromal/endothelial cell protein, 55-KD antibody; BORG 5 antibody; BORG5 antibody; BORG5_HUMAN antibody; CDC42 effector protein (Rho GTPase binding) 1 antibody; Cdc42 effector protein 1 antibody; Cdc42ep1 antibody; CEP 1 antibody; CEP1 antibody; MGC15316 antibody; MSE 55 antibody; MSE55 antibody; OTTHUMP00000028709 antibody; Serum constituent protein antibody; Serum protein MSE55 antibody
Belongs to the BORG/CEP family.
Endothelial and bone marrow stromal cells.
Endomembrane system, Cytoplasm.
MSE55 also known as Borg5 or binder of Rho GTPases 5 is a Cdc42 effector protein that induces long cellular extensions in fibroblasts. MSE55 also increases and mediates actin cytoskeleton reorganization at the plasma membrane. MSE55 is a nonkinase CRIB (Cdc42/Rac interactive-binding) domain-containing molecule. An intact CRIB domain is required for the GTP-dependent binding of MSE55 to Cdc42. MSE55 is expressed in a tissue-specific manner in endothelial and bone marrow stromal cells. MSE55 may have a functional role in hematopoiesis or as a negative regulator of Rho GTPase signaling.