Lane 1: Hela cell lysate
Lane 2: Jurkat cell lysate
Recombinant Rabbit monoclonal primary
CDC23 Recombinant Rabbit Monoclonal Antibody [SD08-60] (ET1612-84)
Synthetic peptide within human cdc23 aa 510-560.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
ANAPC8 antibody; Anaphase promoting complex subunit 8 antibody; Anaphase-promoting complex subunit 8 antibody; Apc 8 antibody; APC8 antibody; Cdc 23 antibody; CDC23 antibody; CDC23_HUMAN antibody; cell division cycle 23 antibody; Cell division cycle 23 homolog antibody; Cell division cycle protein 23 antibody; Cell division cycle protein 23 homolog antibody; Cut23 antibody; Cyclosome subunit 8 antibody
Belongs to the APC8/CDC23 family.
Phosphorylated. Phosphorylation on Thr-562 occurs specifically during mitosis.
Cell cycle progression is controlled at a point late in G1 designated Start. Passage through Start requires the activity of the cyclin-dependent protein kinase Cdc28. Transition from G1 to S phase requires the association of Cdc28 with members of the G1 cyclin family. Exit from mitosis and initiation of the next cell cycle requires a complex of proteins designated the anaphase-promoting complex (APC). This complex consists of two proteins, Cdc16 and Cdc27 (also referred to as Snb1), which are involved in limiting DNA replication to once per cell cycle. Cdc23, another component of the APC, is required for both entering and exiting anaphase, and is important for the proper separation of sister chromatids. The APC is thought to be stabilized by Cdc26 (also known as Scd26). In addition to these APC proteins, Cdc5 is also required for completion of mitosis. In contrast, Cdc20 acts as a DNA-damage induced checkpoint, preventing mitosis when DNA damage has occurred.