CDC23 Recombinant Rabbit Monoclonal Antibody [SD08-60] (ET1612-84)

UNIPROT #

Q9UJX2

PROTEIN NAME

CDC23

SYNONYMS

ANAPC8 antibody;Anaphase promoting complex subunit 8 antibody;Anaphase-promoting complex subunit 8 antibody;Apc 8 antibody;APC8 antibody;Cdc 23 antibody;CDC23 antibody;CDC23_HUMAN antibody;cell division cycle 23 antibody;Cell division cycle 23 homolog antibody;Cell division cycle protein 23 antibody;Cell division cycle protein 23 homolog antibody;Cut23 antibody;Cyclosome subunit 8 antibody

SEQUENCE SIMILARITIES

Belongs to the APC8/CDC23 family.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated. Phosphorylation on Thr-562 occurs specifically during mitosis.

SUBCELLULAR LOCATION

Cytosol.

FUNCTION

Cell division cycle 23 homolog (S. cerevisiae), also known as CDC23, is a protein that, in humans, is encoded by the CDC23 gene. The CDC23 protein shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction.