CD8 beta Recombinant Rabbit Monoclonal Antibody [PSH08-98] (HA723051)

UNIPROT #

P10966

PROTEIN NAME

CD8 beta

SYNONYMS

CD8b antigen antibody;CD_antigen=CD8b antibody;CD8 antigen 37 kDa chain antibody;CD8 antigen beta polypeptide 1 (p37) antibody;CD8 antigen beta polypeptide 1 antibody;CD8 antigen, beta chain antibody;CD8 antigen, beta polypeptide 1 (p37) antibody;CD8 antigen, beta polypeptide 1 antibody;CD8 beta antibody;CD8b antibody;CD8b molecule antibody;CD8B_HUMAN antibody;CD8B1 antibody;Flags: Precursor antibody;Leu2 antibody;Ly3 antibody;LYT3 antibody;MGC119115 antibody;OTTHUMP00000160762 antibody;OTTHUMP00000160763 antibody;OX 8 membrane antigen antibody;P37 antibody;T cell surface glycoprotein CD8 antibody;T cell surface glycoprotein CD8 beta chain antibody;T lymphocyte surface glycoprotein beta chain antibody;T-cell surface glycoprotein CD8 beta chain antibody

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). Along with the TCR, the CD8 co-receptor plays a role in T cell signaling and aiding with cytotoxic T cell-antigen interactions. Like the TCR, CD8 binds to a major histocompatibility complex (MHC) molecule, but is specific for the MHC class I protein. There are two isoforms of the protein, alpha and beta, each encoded by a different gene. In humans, both genes are located on chromosome 2 in position 2p12. The CD8 co-receptor is predominantly expressed on the surface of cytotoxic T cells, but can also be found on natural killer cells, cortical thymocytes, and dendritic cells. The CD8 molecule is a marker for cytotoxic T cell population. It is expressed in T cell lymphoblastic lymphoma and hypo-pigmented mycosis fungoides.