CD79a Rabbit Polyclonal Antibody (R1204-4)

UNIPROT #

P11911

PROTEIN NAME

CD79a

SYNONYMS

B lymphocyte-specific MB1 protein antibody;B-cell antigen receptor complex-associated protein alpha chain antibody;CD 79a antibody;CD79a antibody;CD79a antigen (immunoglobulin-associated alpha) antibody;CD79A antigen antibody;CD79a molecule, immunoglobulin-associated alpha antibody;CD79A_HUMAN antibody;Ig alpha antibody;Ig-alpha antibody;IGA antibody;IgM-alpha antibody;Immunoglobulin-associated alpha antibody;Ly54 antibody;MB-1 membrane glycoprotein antibody;MB1 antibody;Membrane-bound immunoglobulin-associated protein antibody;Surface IgM-associated protein antibody

TISSUE SPECIFICITY

B-cells.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated on tyrosine, serine and threonine residues upon B-cell activation. Phosphorylation of tyrosine residues by Src-family kinases, including LYN, is an early and essential feature of the BCR signaling cascade. The phosphorylated tyrosines serve as docking sites for SH2-domain containing kinases, leading to their activation which in turn leads to phosphorylation of downstream targets. Phosphorylation of serine and threonine residues may prevent subsequent tyrosine phosphorylation.; Arginine methylation in the ITAM domain may interfere with the binding of SYK. It promotes signals leading to B-cell differentiation.

SUBCELLULAR LOCATION

Cell membrane

FUNCTION

The mb-1 gene codes for a phosphoprotein, designated CD79a, that, together with the related CD79b protein, forms a dimer associated with membrane-bound immunoglobulin in B-cells. The CD79a/CD79b dimer is closely associated with the B-cell antigen receptor, in a similar manner to the association of CD3 with the T-cell receptor, and enables the cell to respond to the presence of antigens on its surface. The CD79a protein is present on the surface of B-cells throughout their life cycle, and is absent on all other healthy cells, making it a highly reliable marker for B-cells in immunohistochemistry