CD79a Mouse Monoclonal Antibody [C1-E8] (EM1902-29)

UNIPROT #

P11912

PROTEIN NAME

CD79a

SYNONYMS

B lymphocyte-specific MB1 protein antibody;B-cell antigen receptor complex-associated protein alpha chain antibody;CD 79a antibody;CD79a antibody;CD79a antigen (immunoglobulin-associated alpha) antibody;CD79A antigen antibody;CD79a molecule, immunoglobulin-associated alpha antibody;CD79A_HUMAN antibody;Ig alpha antibody;Ig-alpha antibody;IGA antibody;IgM-alpha antibody;Immunoglobulin-associated alpha antibody;Ly54 antibody;MB-1 membrane glycoprotein antibody;MB1 antibody;Membrane-bound immunoglobulin-associated protein antibody;Surface IgM-associated protein antibody

TISSUE SPECIFICITY

B-cells.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated on tyrosine, serine and threonine residues upon B-cell activation. Phosphorylation of tyrosine residues by Src-family kinases is an early and essential feature of the BCR signaling cascade. The phosphorylated tyrosines serve as docking sites for SH2-domain containing kinases, leading to their activation which in turn leads to phosphorylation of downstream targets. Phosphorylated by LYN. Phosphorylation of serine and threonine residues may prevent subsequent tyrosine phosphorylation.; Arginine methylation in the ITAM domain may interfere with the binding of SYK. It promotes signals leading to B-cell differentiation (By similarity).

SUBCELLULAR LOCATION

Cell membrane, Membrane

FUNCTION

Cluster of differentiation CD79A also known as B-cell antigen receptor complex-associated protein alpha chain and MB-1 membrane glycoprotein, is a protein that in humans is encoded by the CD79A gene. The CD79a protein together with the related CD79b protein, forms a dimer associated with membrane-bound immunoglobulin in B-cells, thus forming the B-cell antigen receptor (BCR). This occurs in a similar manner to the association of CD3 with the T-cell receptor, and enables the cell to respond to the presence of antigens on its surface. It is associated with agammaglobulinemia-3. CD79a plays multiple and diverse roles in B cell development and function. The CD79a/b heterodimer associates non-covalently with the immunoglobulin heavy chain through its transmembrane region, thus forming the BCR along with the immunoglobulin light chain and the pre-BCR when associated with the surrogate light chain in developing B cells. Association of the CD79a/b heterodimer with the immunoglobulin heavy chain is required for surface expression of the BCR and BCR induced calcium flux and protein tyrosine phosphorylation. Genetic deletion of the transmembrane exon of CD79A results in loss of CD79a protein and a complete block of B cell development at the pro to pre B cell transition. Similarly, humans with homozygous splice variants in CD79A predicted to result in loss of the transmembrane region and a truncated or absent protein display agammaglobulinemia and no peripheral B cells.