CD68 Rabbit Polyclonal Antibody (ER1902-74)

UNIPROT #

P34810

PROTEIN NAME

CD68

SYNONYMS

CD 68 antibody;CD68 antibody;CD68 antigen antibody;CD68 molecule antibody;CD68_HUMAN antibody;DKFZp686M18236 antibody;gp11 antibody;Gp110 antibody;LAMP4 antibody;Macrophage antigen CD68 (microsialin) antibody;MACROPHAGE ANTIGEN CD68 antibody;Macrosialin antibody;SCARD1 antibody;Scavenger receptor class D member 1 antibody

SEQUENCE SIMILARITIES

Belongs to the LAMP family.

TISSUE SPECIFICITY

Highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites.

POST-TRANSLATIONAL MODIFICATION

N- and O-glycosylated.

SUBCELLULAR LOCATION

Cell membrane, Endosome, Lysosome, Membrane

FUNCTION

Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells. Highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites.