CD62P Recombinant Rabbit Monoclonal Antibody [JM10-95] (ET1703-49)

UNIPROT #

P16109

PROTEIN NAME

CD62P

SYNONYMS

Antigen CD62 antibody;CD62 antibody;CD62 antigen-like family member P antibody;CD62P antibody;GMP 140 antibody;GMP-140 antibody;GMP140 antibody;GMRP antibody;Granule membrane protein 140 antibody;Granulocyte membrane protein antibody;GRMP antibody;LECAM 3 antibody;LECAM3 antibody;Leukocyte endothelial cell adhesion molecule 3 antibody;Leukocyte-endothelial cell adhesion molecule 3 antibody;LYAM3_HUMAN antibody;P Selectin antibody;P-selectin antibody;PADGEM antibody;Platelet activation dependent granule-external membrane protein antibody;Platelet alpha granule membrane protein antibody;PSEL antibody;Selectin P (granule membrane protein 140kDa, antigen CD62) antibody;SELP antibody

SEQUENCE SIMILARITIES

Belongs to the selectin/LECAM family.

TISSUE SPECIFICITY

Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Selectins, also designated CD62 antigens, comprise a family of carbohydrate-binding proteins involved in mediating cellular interactions with leukocytes. L-Selectin (also designated LECAM-1 or CD62L) is expressed on the majority of B and naive T cells and on most monocytes, neutrophils and eosinophils. L-Selectin interacts with specific carbohydrates expressed by activated endothelial cells. P-Selectin (also designated GMP-140 or CD62P), expressed on activated platelets and endothelial cells, and E-Selectin (also designated ELMA-1 or CD62E), expressed on endothelial cells, exhibit overlapping ligand specificities. Both recognize sialyl-Le (x) as a ligand and bind to specific carbohydrates on neutrophils and monocytes.