CD45 Rabbit Polyclonal Antibody (ER1901-29)

UNIPROT #

P08575

PROTEIN NAME

CD45

SYNONYMS

B220 antibody;CD 45 antibody;CD45 antibody;CD45 antigen antibody;CD45R antibody;GP180 antibody;L-CA antibody;LCA antibody;Leukocyte common antigen antibody;loc antibody;Ly-5 antibody;LY5 antibody;Ly5, homolog of antibody;Lyt-4 antibody;OTTHUMP00000033813 antibody;OTTHUMP00000033816 antibody;OTTHUMP00000033817 antibody;OTTHUMP00000038574 antibody;Protein tyrosine phosphatase receptor type c polypeptide antibody;Protein tyrosine phosphatase, receptor type C antibody;protein tyrosine phosphatase, receptor type, C antibody;Protein tyrosine phosphatase, receptor type, c polypeptide antibody;Ptprc antibody;PTPRC_HUMAN antibody;Receptor-type tyrosine-protein phosphatase C antibody;T200 antibody;T200 glycoprotein antibody;T200 leukocyte common antigen antibody

SEQUENCE SIMILARITIES

Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.

TISSUE SPECIFICITY

Isoform 1: Detected in thymocytes. Isoform 2: Detected in thymocytes. Isoform 3: Detected in thymocytes. Isoform 4: Not detected in thymocytes. Isoform 5: Detected in thymocytes. Isoform 6: Not detected in thymocytes. Isoform 7: Detected in thymocytes. Isoform 8: Not detected in thymocytes.

DEVELOPMENTAL STAGE

Isoform 1: During T-cell development, expressed at the CD3-CD4-CD8- and CD3+CD4+CD8- stages but barely detectable at the CD3-CD4+CD8+ stage. Isoform 2: During T-cell development, expressed at low levels at the CD3-CD4-CD8- and CD3-CD4+CD8- stages but up-regulated at the CD3+CD4+CD8+ and CD3+CD4+CD8- stages. Isoform 3: During T-cell development, expressed at the CD3-CD4-CD8- and CD3+CD4+CD8- stages but barely detectable at the CD3-CD4+CD8+ stage. Isoform 5: During T-cell development, expressed at the CD3-CD4-CD8- and CD3+CD4+CD8- stages but barely detectable at the CD3-CD4+CD8+ stage. Isoform 7: Consistently expressed at high levels at all stages of T-cell development.

POST-TRANSLATIONAL MODIFICATION

Heavily N- and O-glycosylated.

SUBCELLULAR LOCATION

Cell membrane, Membrane raft.

FUNCTION

Protein tyrosine phosphatase, receptor type, C also known as PTPRC is an enzyme that, in humans, is encoded by the PTPRC gene. PTPRC is also known as CD45 antigen (CD stands for cluster of differentiation), which was originally called leukocyte common antigen (LCA). The protein product of this gene, best known as CD45, is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. CD45 contains an extracellular domain, a single transmembrane segment, and two tandem intracytoplasmic catalytic domains, and thus belongs to the receptor type PTP family. CD45 is a type I transmembrane protein that is present in various isoforms on all differentiated hematopoietic cells (except erythrocytes and plasma cells). CD45 has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes via its extracellular domain (a form of co-stimulation), or by activating various Src family kinases required for the antigen receptor signaling via its cytoplasmic domain. CD45 also suppresses JAK kinases, and so functions as a negative regulator of cytokine receptor signaling.