Rabbit polyclonal primary
CD42b Rabbit Polyclonal Antibody (ER1803-26)
Recombinant protein within human cd42b aa 117-328 / 652.
Jurkat, human spleen tissue.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Protein affinity purified.
71 kDa (Predicted band size)
Antigen CD42b alpha antibody; BDPLT1 antibody; BDPLT3 antibody; BSS antibody; CD 42b antibody; CD42b alpha antibody; CD42B antibody; CD42b antigen antibody; DBPLT3 antibody; GLYCOCALICIN antibody; Glycoprotein Ib (platelet) alpha polypeptide antibody; Glycoprotein Ibalpha antibody; GP Ib alpha antibody; GP1B antibody; GP1BA antibody; GPIb alpha antibody; GPIbA antibody; MGC34595 antibody; Platelet glycoprotein Ib alpha chain antibody; Platelet glycoprotein Ib alpha polypeptide antibody; Platelet membrane glycoprotein 1b alpha subunit antibody; VWDP antibody
Glycocalicin is the product of a proteolytic cleavage/shedding, catalyzed by ADAM17, which releases most of the extracellular domain. Binding sites for vWF and thrombin are in this part of the protein.
CD42a is a single-chain membrane glycoprotein that forms a noncovalent complex with CD42b. CD42b, also known as glycoprotein Ib a (GPIb a) is a membrane glycoprotein that is composed of a and b chains. The CD42b b chain is also designated CD42c, and is expressed on platelets and megakaryocytes. CD42a and CD42b are also present on platelets and mega-karyocytes, and the complex is a major component of the platelet surface. The complex acts as a receptor for von Willebrand's factor and as a von Willebrand's factor-dependent adhesion receptor.