CD42b Rabbit Polyclonal Antibody (ER1803-26)

UNIPROT #

P07359

PROTEIN NAME

CD42b

SYNONYMS

Antigen CD42b alpha antibody;BDPLT1 antibody;BDPLT3 antibody;BSS antibody;CD 42b antibody;CD42b alpha antibody;CD42B antibody;CD42b antigen antibody;DBPLT3 antibody;GLYCOCALICIN antibody;Glycoprotein Ib (platelet) alpha polypeptide antibody;Glycoprotein Ibalpha antibody;GP Ib alpha antibody;GP1B antibody;GP1BA antibody;GPIb alpha antibody;GPIbA antibody;MGC34595 antibody;Platelet glycoprotein Ib alpha chain antibody;Platelet glycoprotein Ib alpha polypeptide antibody;Platelet membrane glycoprotein 1b alpha subunit antibody;VWDP antibody

POST-TRANSLATIONAL MODIFICATION

Glycocalicin is the product of a proteolytic cleavage/shedding, catalyzed by ADAM17, which releases most of the extracellular domain. Binding sites for vWF and thrombin are in this part of the protein.

SUBCELLULAR LOCATION

Membrane. Secreted.

FUNCTION

CD42a is a single-chain membrane glycoprotein that forms a noncovalent complex with CD42b. CD42b, also known as glycoprotein Ib a (GPIb a) is a membrane glycoprotein that is composed of a and b chains. The CD42b b chain is also designated CD42c, and is expressed on platelets and megakaryocytes. CD42a and CD42b are also present on platelets and mega-karyocytes, and the complex is a major component of the platelet surface. The complex acts as a receptor for von Willebrand's factor and as a von Willebrand's factor-dependent adhesion receptor.