CD40 Mouse Monoclonal Antibody [A1E5] (EM1901-41)

UNIPROT #

P25942

PROTEIN NAME

CD40

SYNONYMS

AI326936 antibody;B cell associated molecule CD40 antibody;B cell surface antigen CD40 antibody;B cell-associated molecule antibody;B-cell surface antigen CD40 antibody;Bp50 antibody;CD 40 antibody;CD40 antibody;CD40 antigen (TNF receptor superfamily member 5) antibody;CD40 antigen antibody;CD40 molecule antibody;CD40 molecule, TNF receptor superfamily member 5 antibody;CD40 protein antibody;CD40 type II isoform antibody;CD40L receptor antibody;CDw40 antibody;GP39 antibody;HIGM1 antibody;IGM antibody;IMD3 antibody;MGC9013 antibody;Nerve growth factor receptor related B lymphocyte activation molecule antibody;OTTHUMP00000031699 antibody;OTTHUMP00000031700 antibody;p50 antibody;T-BAM antibody;TBAM antibody;TNF receptor superfamily member 5 antibody;TNFRSF5 antibody;TNR5_HUMAN antibody;TRAP antibody;Tumor necrosis factor receptor superfamily , member 5 antibody;Tumor necrosis factor receptor superfamily member 5 antibody;Tumor necrosis factor receptor superfamily member 5 precursor antibody;Tumor necrosis factor receptor superfamily, member 5, isoform CRA_a antibody

TISSUE SPECIFICITY

B-cells and in primary carcinomas.

SUBCELLULAR LOCATION

Cell membrane, secreted.

FUNCTION

This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.