CD4 Rabbit Polyclonal Antibody (R1211-1)

UNIPROT #

P01730

PROTEIN NAME

CD4

SYNONYMS

CD 4 antibody;CD4 (L3T4) antibody;CD4 antibody;CD4 antigen (p55) antibody;CD4 antigen antibody;CD4 molecule antibody;CD4 receptor antibody;CD4+ Lymphocyte deficiency, included antibody;CD4_HUMAN antibody;CD4mut antibody;L3T4 antibody;Leu3 antibody;Ly-4 antibody;Lymphocyte antigen CD4 antibody;MGC165891 antibody;OTTHUMP00000238897 antibody;p55 antibody;T cell antigen T4 antibody;T cell antigen T4/LEU3 antibody;T cell differentiation antigen L3T4 antibody;T cell OKT4 deficiency, included antibody;T cell surface antigen T4/Leu 3 antibody;T cell surface antigen T4/Leu3 antibody;T cell surface glycoprotein CD4 antibody;T-cell surface antigen T4/Leu-3 antibody;T-cell surface glycoprotein CD4 antibody;W3/25 antibody;W3/25 antigen antibody

TISSUE SPECIFICITY

Highly expressed in T-helper cells. The presence of CD4 is a hallmark of T-helper cells which are specialized in the activation and growth of cytotoxic T-cells, regulation of B cells, or activation of phagocytes. CD4 is also present in other immune cells such as macrophages, dendritic cells or NK cells.

POST-TRANSLATIONAL MODIFICATION

Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.; Phosphorylated by PKC; phosphorylation at Ser-433 plays an important role for CD4 internalization.

SUBCELLULAR LOCATION

Cell membrane

FUNCTION

The CD4 gene encodes the T4 antigen, a glycoprotein of approximately 55 kDa, expressed on the surface of helper T lymphocytes.CD4 antigens are members of the immunoglobulin supergene family and are implicated as associative recognition elements in major histocompatibility complex class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. CD4 antigens also serve as interleukin-15 receptors and bind to the HIV receptors, binding directly to the HIV envelope protein GP120.