Rabbit polyclonal primary
CD4 Rabbit Polyclonal Antibody (0108-6)
This antibody is produced by immunizing rabbits with a synthetic peptide (klh-coupled) corresponding to mouse cd4 aa 200-250.
Mouse brain tissue, LOVO, Raji.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 25% Glycerol. Preservative: 0.05% Sodium Azide.
Peptide affinity purified
CD 4 antibody; CD4 (L3T4) antibody; CD4 antibody; CD4 antigen (p55) antibody; CD4 antigen antibody; CD4 molecule antibody; CD4 receptor antibody; CD4+ Lymphocyte deficiency, included antibody; CD4_HUMAN antibody; CD4mut antibody; L3T4 antibody; Leu3 antibody; Ly-4 antibody; Lymphocyte antigen CD4 antibody; MGC165891 antibody; OTTHUMP00000238897 antibody; p55 antibody; T cell antigen T4 antibody; T cell antigen T4/LEU3 antibody; T cell differentiation antigen L3T4 antibody; T cell OKT4 deficiency, included antibody; T cell surface antigen T4/Leu 3 antibody; T cell surface antigen T4/Leu3 antibody; T cell surface glycoprotein CD4 antibody; T-cell surface antigen T4/Leu-3 antibody; T-cell surface glycoprotein CD4 antibody; W3/25 antibody; W3/25 antigen antibody
Highly expressed in T-helper cells. The presence of CD4 is a hallmark of T-helper cells which are specialized in the activation and growth of cytotoxic T-cells, regulation of B cells, or activation of phagocytes. CD4 is also present in other immune cells such as macrophages, dendritic cells or NK cells.
Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.; Phosphorylated by PKC; phosphorylation at Ser-433 plays an important role for CD4 internalization.
The CD4 gene encodes the T4 antigen, a glycoprotein of approximately 55 kDa, expressed on the surface of helper T lymphocytes.CD4 antigens are members of the immunoglobulin supergene family and are implicated as associative recognition elements in major histocompatibility complex class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. CD4 antigens also serve as interleukin-15 receptors and bind to the HIV receptors, binding directly to the HIV envelope protein GP120.