CD38 Recombinant Antibody [PD01-49] - Rat IgG1 (Chimeric) (HA601417)

UNIPROT #

P28907

PROTEIN NAME

CD38

SYNONYMS

Acute lymphoblastic leukemia cells antigen CD38 antibody;ADP ribosyl cyclase 1 antibody;ADP ribosyl cyclase antibody;ADP ribosyl cyclase/cyclic ADP-ribose hydrolase antibody;ADP-ribosyl cyclase 1 antibody;ADPRC 1 antibody;ADPRC1 antibody;cADPr hydrolase 1 antibody;CD 38 antibody;CD38 antibody;CD38 antigen (p45) antibody;CD38 antigen antibody;CD38 molecule antibody;Cd38-rs1 antibody;CD38_HUMAN antibody;CD38H antibody;Cyclic ADP ribose hydrolase antibody;Cyclic ADP ribose hydrolase 1 antibody;Cyclic ADP-ribose hydrolase 1 antibody;EC 3.2.2.5 antibody;Ecto nicotinamide adenine dinucleotide glycohydrolase antibody;I-19 antibody;I19 (mouse) antibody;Lymphocyte differentiation antigen CD38 antibody;NAD(+) nucleosidase antibody;NIM-R5 antigen antibody;NIMR5 antigen (mouse) antibody;OTTHUMP00000158633 antibody;OTTHUMP00000217743 antibody;p45 antibody;T10 antibody

SUBCELLULAR LOCATION

Membrane.

FUNCTION

CD38 (cluster of differentiation 38), also known as cyclic ADP ribose hydrolase is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B lymphocytes and natural killer cells. CD38 also functions in cell adhesion, signal transduction and calcium signaling. CD38 can function either as a receptor or as an enzyme. As a receptor, CD38 can attach to CD31 on the surface of T cells, thereby activating those cells to produce a variety of cytokines. CD38 is a multifunctional enzyme that catalyzes the synthesis of ADP ribose (ADPR) (97%) and cyclic ADP-ribose (cADPR) (3%) from NAD+. CD38 is thought to be a major regulator of NAD+ levels, its NADase activity is much higher than its function as an ADP-rybosyl-cyclase: for every 100 molecules of NAD+ converted to ADP ribose it generates one molecule of cADPR. When nicotinic acid is present under acidic conditions, CD38 can hydrolyze nicotinamide adenine dinucleotide phosphate (NADP+) to NAADP. These reaction products are essential for the regulation of intracellular Ca2+. CD38 occurs not only as an ectoenzyme on cell outer surfaces, but also occurs on the inner surface of cell membranes, facing the cytosol performing the same enzymatic functions. CD38 is believed to control or influence neurotransmitter release in the brain by producing cADPR. CD38 within the brain enables release of the affiliative neuropeptide oxytocin. Like CD38, CD157 is a member of the ADP-ribosyl cyclase family of enzymes that catalyze the formation of cADPR from NAD+, although CD157 is a much weaker catalyst than CD38. The SARM1 enzyme also catalyzes the formation of cADPR from NAD+, but SARM1 elevates cADPR much more efficiently than CD38.