CD38 Recombinant Rabbit Monoclonal Antibody [SN07-20] (ET1611-66)

UNIPROT #

P28907

PROTEIN NAME

CD38

SYNONYMS

Acute lymphoblastic leukemia cells antigen CD38 antibody;ADP ribosyl cyclase 1 antibody;ADP ribosyl cyclase antibody;ADP ribosyl cyclase/cyclic ADP-ribose hydrolase antibody;ADP-ribosyl cyclase 1 antibody;ADPRC 1 antibody;ADPRC1 antibody;cADPr hydrolase 1 antibody;CD 38 antibody;CD38 antibody;CD38 antigen (p45) antibody;CD38 antigen antibody;CD38 molecule antibody;Cd38-rs1 antibody;CD38_HUMAN antibody;CD38H antibody;Cyclic ADP ribose hydrolase antibody;Cyclic ADP ribose hydrolase 1 antibody;Cyclic ADP-ribose hydrolase 1 antibody;EC 3.2.2.5 antibody;Ecto nicotinamide adenine dinucleotide glycohydrolase antibody;I-19 antibody;I19 (mouse) antibody;Lymphocyte differentiation antigen CD38 antibody;NAD(+) nucleosidase antibody;NIM-R5 antigen antibody;NIMR5 antigen (mouse) antibody;OTTHUMP00000158633 antibody;OTTHUMP00000217743 antibody;p45 antibody;T10 antibody

SEQUENCE SIMILARITIES

Belongs to the ADP-ribosyl cyclase family.

TISSUE SPECIFICITY

Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.

DEVELOPMENTAL STAGE

Preferentially expressed at both early and late stages of the B and T-cell maturation. It is also detected on erythroid and myeloid progenitors in bone marrow, where the level of surface expression was shown to decrease during differentiation of blast-forming unit E to colony-forming unit E.

SUBCELLULAR LOCATION

Membrane.

FUNCTION

CD38 is a type II integral membrane glycoprotein which is present on early B and T cell lineages and activated B and T cells but is absent from most mature resting peripheral lymphocytes. CD38 is also found on thymocytes, pre-B cells, germinal center B cells, mitogen-activated T cells, monocytes and Ig-secreting plasma cells. CD38 acts as a NAD glycohydrolase in T lymphocytes. On hematopoietic cells CD38 induces activation, proliferation, and differentiation of mature T and B cells and mediates apoptosis of myeloid and lymphoid progenitor cells. In addition to acting as a signaling receptor, CD38 is also an enzyme capable of producing several calcium-mobilizing metabolites, including cyclic adenosine diphosphate ribose (cADPR). CD38 also plays a role in maintaining survival of an invariant NK T (iNKT) cell subset that preferentially contributes to the maintenance of immunological tolerance.