CD38 Recombinant Rabbit Monoclonal Antibody [JE29-35] (ET7110-53)

UNIPROT #

P28907

PROTEIN NAME

CD38

SYNONYMS

Acute lymphoblastic leukemia cells antigen CD38 antibody;ADP ribosyl cyclase 1 antibody;ADP ribosyl cyclase antibody;ADP ribosyl cyclase/cyclic ADP-ribose hydrolase antibody;ADP-ribosyl cyclase 1 antibody;ADPRC 1 antibody;ADPRC1 antibody;cADPr hydrolase 1 antibody;CD 38 antibody;CD38 antibody;CD38 antigen (p45) antibody;CD38 antigen antibody;CD38 molecule antibody;Cd38-rs1 antibody;CD38_HUMAN antibody;CD38H antibody;Cyclic ADP ribose hydrolase antibody;Cyclic ADP ribose hydrolase 1 antibody;Cyclic ADP-ribose hydrolase 1 antibody;EC 3.2.2.5 antibody;Ecto nicotinamide adenine dinucleotide glycohydrolase antibody;I-19 antibody;I19 (mouse) antibody;Lymphocyte differentiation antigen CD38 antibody;NAD(+) nucleosidase antibody;NIM-R5 antigen antibody;NIMR5 antigen (mouse) antibody;OTTHUMP00000158633 antibody;OTTHUMP00000217743 antibody;p45 antibody;T10 antibody

SEQUENCE SIMILARITIES

Belongs to the ADP-ribosyl cyclase family.

TISSUE SPECIFICITY

Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.

DEVELOPMENTAL STAGE

Preferentially expressed at both early and late stages of the B and T-cell maturation. It is also detected on erythroid and myeloid progenitors in bone marrow, where the level of surface expression was shown to decrease during differentiation of blast-forming unit E to colony-forming unit E.

SUBCELLULAR LOCATION

Membrane.

FUNCTION

The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants.