CD36 Recombinant Rabbit Monoclonal Antibody [JJ2005] (ET1701-24)

UNIPROT #

P16671

PROTEIN NAME

CD36

SYNONYMS

Adipocyte membrane protein antibody;BDPLT10 antibody;CD36 antibody;CD36 antigen (collagen type I receptor, thrombospondin receptor) antibody;CD36 antigen antibody;CD36 molecule (thrombospondin receptor) antibody;CD36 molecule antibody;CD36_HUMAN antibody;CHDS7 antibody;Cluster determinant 36 antibody;Collagen receptor, platelet antibody;FAT antibody;Fatty acid translocase antibody;Fatty acid transport protein antibody;Glycoprotein IIIb antibody;GP IIIb antibody;GP3B antibody;GP4 antibody;GPIIIB antibody;GPIV antibody;Leukocyte differentiation antigen CD36 antibody;MGC108510 antibody;MGC91634 antibody;PAS 4 protein antibody;PAS IV antibody;PAS-4 antibody;PASIV antibody;Platelet collagen receptor antibody;Platelet glycoprotein 4 antibody;Platelet glycoprotein IV antibody;scarb3 antibody;Scavenger receptor class B member 3 antibody;Thrombospondin receptor antibody

SEQUENCE SIMILARITIES

Belongs to the CD36 family.

POST-TRANSLATIONAL MODIFICATION

N-glycosylated and O-glycosylated with a ratio of 2:1.; Ubiquitinated at Lys-469 and Lys-472. Ubiquitination is induced by fatty acids such as oleic acid and leads to degradation by the proteasome. Ubiquitination and degradation are inhibited by insulin which blocks the effect of fatty acids.

SUBCELLULAR LOCATION

Cell membrane, Membrane raft, Golgi apparatus, Apical cell membrane.

FUNCTION

CD36 (cluster of differentiation 36), also known as platelet glycoprotein 4, fatty acid translocase (FAT), scavenger receptor class B member 3 (SCARB3), and glycoproteins 88 (GP88), IIIb (GPIIIB), or IV (GPIV) is a protein that in humans is encoded by the CD36 gene. The CD36 antigen is an integral membrane protein found on the surface of many cell types in vertebrate animals. It imports fatty acids inside cells and is a member of the class B scavenger receptor family of cell surface proteins. CD36 binds many ligands including collagen, thrombospondin, erythrocytes parasitized with Plasmodium falciparum, oxidized low density lipoprotein, native lipoproteins, oxidized phospholipids, and long-chain fatty acids. Work in genetically modified rodents suggest a role for CD36 in fatty acid metabolism, heart disease, taste, and dietary fat processing in the intestine. It may be involved in glucose intolerance, atherosclerosis, arterial hypertension, diabetes, cardiomyopathy, Alzheimer's disease and various cancers, mostly of epithelial origin (breast, prostate, ovary, and colon) and also for hepatic carcinoma and gliomas.