CD35 Mouse Monoclonal Antibody [A4F3] (HA601022)

UNIPROT #

P17927

PROTEIN NAME

CD35

SYNONYMS

C3 binding protein antibody;C3b/C4b receptor antibody;C3BR antibody;C4BR antibody;CD 35 antibody;CD35 antibody;CD35 antigen antibody;complement component (3b/4b) receptor 1 (Knops blood group) antibody;complement component (3b/4b) receptor 1 including Knops blood group system antibody;Complement component receptor 1 antibody;Complement receptor 1 antibody;Complement receptor type 1 antibody;CR 1 antibody;CR1 antibody;CR1_HUMAN antibody;KN antibody;Knops blood group antigen antibody

SUBCELLULAR LOCATION

Membrane.

FUNCTION

Complement receptor type 1 (CR1) also known as C3b/C4b receptor or CD35 (cluster of differentiation 35) is a protein that in humans is encoded by the CR1 gene. This gene is a member of the regulators of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, hyalocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized.